应用
Thiazole is used as a flavoring agent and in the preparation of dyes and rubber accelerators. It serves as a component of the vitamin thiamine (B1). It acts as a protected formyl group used in natural product synthesis. It reacts with alkyl lithium and Grignard?’s reagent to prepare organometallic complexes. It is involved in the electrophilic aromatic substitution and nucleophilic aromatic substitution at C-5 and C-2 positions respectively. Further, it undergoes alkylation reaction to get thiazolium cation, which is used as a catalyst in the Stetter reaction and the Benzoin condensation. In addition to this, it is involved in the preparation of alagebrium.

备注
Air and light sensitive. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents and carbon dioxide.

基本信息

MDL
MFCD00005315

EINECS
206-021-3

分子式
C₃H₃NS

分子量
85.13

熔点
-33°

沸点
117-118°

闪点
22°(71°F)

密度
1.200

折射率
1.5390

灵敏度
Air Sensitive. Light Sensitive. Store under Nitrogen. Ambient temperatures.

形态
Liquid

溶解性
Soluble in ethanol and ether. Slightly soluble in water.

Beilstein
103852

Merck
14,9307

GHS危害和防范说明

GHS符号

Hazard Statements
H225-H302-H319
Highly flammable liquid and vapour.Harmful if swallowed.Causes serious eye irritation.

Precautionary Statements
P210-P261-P280f-P305+P351+P338
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective clothing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

安全信息

危险等级
3

包装组
III

危险类别
10-22-36
Flammable.Harmful if swallowed.Irritating to eyes.

安全等级
23-26-36-60
Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
XJ1290000

TSCA
是