应用
N-Methoxymethyl-N-(trimethylsilylmethyl)benzylamine forms azomethine ylides which readily undergo [3+2] cycloaddition to α,??-unsaturated esters affording N-benzyl substituted pyrrolidines in good yields. It reacts with asymmetric 1,3-dipolar cycloadditions in the practical, large-scale synthesis of chiral pyrrolidines. It is used in the the synthesis of 3-carboxy-1-azabicyclo[2.2.1]heptane derivatives, an important class of physiologically active compounds.

备注
Moisture & Light Sensitive. Store away from oxidizing agents.

基本信息

MDL
MFCD00674005

EINECS
000-000-0

分子式
C₁₃H₂₃NOSi

分子量
237.42

沸点
76°/0.3mm

闪点
66°(150°F)

密度
0.928

折射率
1.4920

灵敏度
Keep Cold. Moisture Sensitive. Light Sensitive. Store under Nitrogen.

形态
Liquid

溶解性
Soluble in chloroform, ethyl acetate.

Beilstein
4311216

GHS危害和防范说明

GHS符号

Hazard Statements
H227-H315-H319-H335
Combustible liquid.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P210e-P261-P280a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

TSCA
否