应用
N,N'-Dicyclohexylcarbodiimide is a carboxyl activating reagent used in peptide synthesis. It acts as a dehydrating agent for the preparation of amides, ketones and nitriles. It is involved in the preparation of esters by reacting tertiary alcohols with carboxylic acid. It is utilized for the stereo chemical inversion of secondary alcohols by forming formyl ester followed by saponification. It is associated with dimethyl sulfoxide and used in Pfitzner-Moffatt oxidation to convert alcohols into aldehydes and ketones.

备注
Incompatible with strong oxidizing agents.

基本信息

MDL
MFCD00011659

EINECS
208-704-1

分子式
C₁₃H₂₂N₂

分子量
206.33

熔点
33-36°

沸点
154-156°/11mm

闪点
138°(280°F)

灵敏度
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.

形态
Solid

溶解性
Soluble in methanol, chloroform, dichloromethane, acetonitrile, tetrahydrofuran and dimethylformamide. Insoluble in water.

Beilstein
610662

Merck
14,3096

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H311-H318-H317
Harmful if swallowed.Toxic in contact with skin.Causes serious eye damage.May cause an allergic skin reaction.

Precautionary Statements
P261-P280-P305+P351+P338-P310a-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
6.1

包装组
III

危险类别
22-24-41-43
Harmful if swallowed.Toxic in contact with skin.Risk of serious damage to eyes.May cause sensitization by skin contact.

安全等级
24-26-37/39-45
Avoid contact with skin.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

RTECS
FF2160000

TSCA
是