应用
It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst??15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

备注
Hygroscopic. Store away from oxidizing agents and bases. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

基本信息

MDL
MFCD00012826

EINECS
217-350-7

分子式
C₆H₆₂N?HCl

分子量
164.04

熔点
166-171°

灵敏度
Hygroscopic. Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in water (750 mg/ml at 20°C), soluble in 1N HCl (2.5%), DMSO, and methanol.

Beilstein
3689154

GHS危害和防范说明

GHS符号

Hazard Statements
H301-H311-H314-H318-H317
Toxic if swallowed.Toxic in contact with skin.Causes severe skin burns and eye damage.Causes serious eye damage.May cause an allergic skin reaction.

Precautionary Statements
P260h-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
8

包装组
III

危险类别
21/22-34-43
Harmful in contact with skin and if swallowed.Causes burns.May cause sensitization by skin contact.

安全等级
24-26-36/37/39-45
Avoid contact with skin.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

欧盟危险品标志

TSCA
否