应用
1-Chloroethyl chloroformate acts as a reagent in the selective N-dealkylation of tertiary amines. It is also used as a reactant in the preparation of alkyl 1-chloroethyl carbonates. Further, it is used for N-demethylation reaction in the determination of multiple drugs of abuse in biological fluids using capillary electrophoresis with native fluorescence and laser-induced fluorescence detection. It plays an important role as a catalyst for the chemoselective desilylation of silyl-protected alcohols. In addition to this, it is used to cleave benzhydryl groups from amines.

备注
Moisture sensitive. Store in a cool place. Incompatible with strong oxidizing agent, strong base, alcohols and amines.

基本信息

MDL
MFCD00000647

EINECS
256-834-2

分子式
C₃H₄Cl₂O₂

分子量
142.97

熔点
-65°

沸点
119-121°

闪点
45°(113°F)

密度
1.312

折射率
1.4230

灵敏度
Keep Cold. Moisture Sensitive.

溶解性
Miscible with most organic solvents.

Beilstein
1747601

GHS危害和防范说明

GHS符号

Hazard Statements
H226-H302-H330-H314-H318
Flammable liquid and vapour.Harmful if swallowed.Fatal if inhaled.Causes severe skin burns and eye damage.Causes serious eye damage.

Precautionary Statements
P303+P361+P353-P304+P340-P305+P351+P338-P320-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Specific treatment is urgent (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
6.1

包装组
II

危险类别
10-22-23-34
Flammable.Harmful if swallowed.Toxic by inhalation.Causes burns.

安全等级
26-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

TSCA
否