应用
4-Bromobenzonitrile is used as reagents and solvents. Reaction of 2-propanol, 4-bromobenzonitrile, and NaH in the presence of 1.5 mol % Pd2(dba)3 and 3 mol % (S)-(-)2,2?-bis(di-p-tolylphosphino)- 1,1?-binaphthyl at 50?°C afforded 4-isopropoxy- benzonitrile in 80% isolated yield. The synthesis of 4-cyanobiphenyl at room temperature in a flow injection microreactor, using a supported catalyst, without the addition of a base gave a product yield of 67?±7% (n=6). This was achieved by injecting 4-bromobenzonitrile. The 3-arylation of 2,5-dimethylthiophene with 4-bromopropiophenone, 4-trifluoromethylbromobenzene or 4-bromobenzonitrile gave 3-5 in only 38-50% yields in Palladium-catalysed direct 3-or 4-arylation of thiophene derivatives using aryl bromides.

备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

基本信息

MDL
MFCD00001811

EINECS
210-764-9

分子式
C₇H₄BrN

分子量
182.03

熔点
111-114°

沸点
235-237°

闪点
130°(266°F)

密度
1.562

灵敏度
Ambient temperatures.

形态
Crystalline powder

溶解性
Very slightly soluble in water(0.2g/L). Soluble in alcohol and ether.

Beilstein
2041518

GHS危害和防范说明

GHS符号

Hazard Statements
H301-H312-H331-H315-H319-H335-H402-H412
Toxic if swallowed.Harmful in contact with skin.Toxic if inhaled.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.Harmful to aquatic life.Harmful to aquatic life with long lasting effects.

Precautionary Statements
P261-P280-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/protective clothing/eye protection/face protection.Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
20/21/22-36/37/38-52/53
Harmful by inhalation, in contact with skin and if swallowed.Irritating to eyes, respiratory system and skin.Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

安全等级
26-36/37-61
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.Avoid release to the environment. Refer to special instructions/safety data sheets.

欧盟危险品标志

RTECS
DI2460000

TSCA
否