应用
Methanetricarboxylates have been used as "blocked" malonic esters, restricting reaction with alkyl halides to monoalkylation. The unwanted carboxyl group can be removed by treatment with Na alkoxide, LDA or BCl3. Provides a useful 2-carbon chain extension method that adds to Michael acceptors under phase-transfer conditions. Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors.

备注
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

基本信息

MDL
MFCD00009150

EINECS
228-477-2

分子式
C₁₀H₁₆O₆

分子量
232.23

熔点
26-29°

沸点
253°

闪点
>110°(230°F)

密度
1.095

折射率
1.4255

灵敏度
Ambient temperatures.

溶解性
Insoluble in water.

Beilstein
1793645

安全信息

TSCA
否